Endocrine Abstracts

Rathke’s cleft cysts (RCCs) are benign epithelium-lined cystic remnants of the embryonic Rathke’s pouch. We report a case of a previously fit and well 30-year-old lady with an incidental finding of a cystic pituitary lesion, discovered when she took part in a clinical trial as a normal volunteer. She had no history to suggest endocrine dysfunction.Pituitary function tests showed prolactin 302 mU/l (ref <630), LH 2.2 U/l, FSH 4.9 U/l, oestra...

Congenital fibrous dysplasia is a rare disease with a broad spectrum of manifestations, including various endocrinopathies;precocious puberty, hyperthyroidism, excess growth hormone, hypophosphatemia mediated by FGF23.We present the case of a 33 year old male, who presented in our endocrinology service with infertility and bone pain. He was diagnosed at the age of years old with congenital fibrous dyplasia and suffered multiple surgeries for bone decompr...

A 72-year-old man, otherwise fit and well, with treated hypertension presented to our hospital with abdominal pain and vomiting. He was febrile with deranged liver function tests and elevated inflammatory markers. Abdominal ultrasound showed a right suprarenal mass, and a normal gallbladder.CT confirmed a 37×31×24 mm right adrenal mass with no significant contrast enhancement, and bilateral pneumonia responsible for the septic picture. Thrombus...

Introduction: Parathyroid carcinoma is a rare endocrine malignancy accounting for <1% of all cases of hyperparathyroidism. Diagnosis and treatment is still difficult.Case report: A 32-year-old women was admitted to the hospital because of mental status changes, polyuria, polydipsia, musculoskeletal pain and weight loss (34 kg during last year). She had history of nephrolithiasis, pancreatitis, cholelithiasis, peptic ulcer disease, osteoporosis and di...

A 73 years old man came to our observation for severe dysphagia and loss of weight (10 kg in 1 month). About 30 years before he had myocardial infarction and he underwent coronary artery bypass graft. One week before the first medical evaluation, patient suspended all drugs per os because he could not swallow pills and food. Thyroid function test revealed a severe hyperthyroidism (FT3 11.9 pg/ml; FT4 40 pg/ml; TSH <0.01 μU/ml). Anti-TSH ...

Autoimmune polyglandular syndrome type I is a very rare disorder. We present the case of a six-year-old girl admitted to our hospital in September 1999 for recurring seizures and a history of muscle cramps and carpal spasms. Neurological examination showed congenital partial palsy of cranial nerves III and VI, EEG revealed abnormal electric activity and cerebral CT was normal. Laboratory findings (hypocalcemia-5 mg/dl, hyperphosphatemia-10.3 mg/dl and low serum PTH level-4.72 ...

Background: The combination of a toxic adenoma and Graves’ disease compose the Marine-Lenhart syndrome. It is estimated to occur in 0.8–2.7% of Graves’ disease and only few are reported.Case presentation: A 29-year old female was referred to our clinic due to subclinical hyperthyroidism and a newly discovered thyroid nodule on the right thyroid lobe. She had no thyreotoxic symptoms and the clinical examination was unremarkable. The blood t...

A 47-year-old male with a history of severe persistent asthma and recurrent respiratory infections with admissions to the Pulmonology Department. The patient underwent a study due to weight loss, diarrhoea and Ca 19.9 elevation. Imaging tests (abdominal CT and MRI cholangio) were performed, which highlighted severe pancreatic fat infiltration. The cystic fibrosis study was completed with genetics (positive: two heterozygous switches F508del and D1152H), sweat test (45 mmol/l -...

Thyroid storm (TS) is a rare and life threatening condition that requires a prompt recognition and treatment. The clinical features may overlap with other acute medical conditions. Currently both Akamizu Criteria (JTA) and Burch and Wartofsky Scale (BW) are helpful diagnostics tools.Objective: To evaluate TS patients according to currently available criteria and to identify the clinical features and outcomes.Methods: A single cente...

Objective: To report a case of hypogonadism reversal and spontaneous puberty in a craniopharyngioma patient who suffered from hypopituitarism as a result of complete surgical resection.Methods: A 13-year-old boy with hypopituitarism was evaluated for right testicular sensitivity.At the age of 6 the child presented with growth arrest and a craniopharyngioma causing pituitary insufficiency was diagnosed. Treatment with hydrocortisnon...